Despite deromantizing total synthesis I do like organic chemistry and do feel aesthetic pleasure from synthetic schemes and mechanisms [note for my future employer, I do enjoy the bench work, too!]. Also, since high school and undergrad years I still have weak spot for org-chem puzzles. So Below are some little nuggets (subjective, of course) from the recent OC papers that I found interesting.
From Popov et al (Somfai lab) (ACIE):
- Try to figure out the mechanism
- Try to explain the difference in chemoselectivity (and what’s going on with that Ts group by the way?).
From Hamasaki et al (Kochi lab) (JACS)
Can you guess the mechanism for this one?
All multi-ton processes start from the small scale, check this cute Kugelrohr apparatus setup by Thiyagarajan et al. for processing of biomass-derived furans (The white stuff in the middle is a zeolite catalyst; ACIE)