Some things organic chemists should borrow from bio lab

Since I’ve shifted from ‘pure’ synthetic chemistry lab to chemical biology, my set of labware has also changed from borosilicate glassware to polypropylene plasticware. And, you know what, I wish it happened years earlier. Here are some awesome little things that make my synthetic life easier today. Continue reading “Some things organic chemists should borrow from bio lab”

Finding new pockets with fragments

Fragment-based design is one of my favorite approaches in drug discovery. It has everything from very simple conception to sophisticated data analysis. The most importantly, it works as it’s supposed to. So it’s always entertaining to find a paper from the very founders of FBDD, I mean Astex Pharmaceuticals and Harren Jhoti himself. Continue reading “Finding new pockets with fragments”