Couple of days ago I’ve come across a recent paper in Nature with quite an eyebrow-raising title “A trans-synaptic nanocolumn aligns neurotransmitter release to receptors“. The title made me think as if the authors have observed hitherto unknown structures in the synaptic cleft. That would be quite a sensation! But then this sentence comes in the abstract:
These presynaptic RIM nanoclusters closely align with concentrated postsynaptic receptors and scaffolding proteins4, 5, 6, suggesting the existence of a trans-synaptic molecular ‘nanocolumn’.
Now it looked like they propose some kind of neuroscience equivalent of dark matter. You know, something that nobody knows what it is, but that certainly must be there, otherwise there’s no explanation to what we see. Continue reading “Skepticism about synaptic nanocolumns”
I couldn’t find a free software that would easily do exactly what I want (see the subject). So here’s my ghetto solution, which can be easily automated. Continue reading “Extracting ChemDraw schemes as .cdx files from MS Word/Excel/PowerPoint documents”
Regular readers of this blog (all five of you, guys) have probably noticed that nothing appeared here in the past two months. As one could guess from the energy conservation law, my activity was mainly concentrated offline during this time. As a quick summary, I have left academia and landed an industry job as a research chemist in a small biotech company. And, quite surprisingly, this blog played a crucial role in this dramatic transition. Continue reading “Can blog writing get you a real job?”
It’s hard to imagine more intriguing title in Angewandte Chemie International Edition than “Astringent Mouthfeel as a Consequence of Lubrication Failure“. The first impression doesn’t deceive, and the paper is really interesting and fun to read. Somehow manifestations of molecular interactions in the macroscopic world never stop amusing me. And this communication is exactly about such emergent effect. Continue reading “Molecular tribology”
Simplification of complex structures is one way medicinal chemists avoid lengthy (and risky) synthetic routes to the analogs of natural products. And it’s absolutely rational, if one can get the same pharmacological effect with a simple molecule, why bother making a complex 3D scaffold? One classic med-chem textbook example is simplification of morphine scaffold to pethidine that led eventually to the development of fentanyl.
Continue reading “MedChem shortcuts”
A couple of weeks ago I attended a presentation given by Lisa Stowers from Scripps, entitled “Decision-making in the nose: a molecular rationale for the unpredictable nature of female behavior”. The catchy title did its job, so I was there, learning that reaction of female mice on male pheromones depends on (suprise-surprise!) phase of their estrous cycle. The neurobiology behind it is quite amazing, definitely worth reading about. However, my interest was triggered by one question asked after the presentation.
Continue reading “Pheromone puzzle”
Kawamura et al. (Baran lab, Nature)
A paper with a very straightforward title, “Nineteen-step total synthesis of (+)-phorbol” (neither “concise”, nor “efficient”, “elegant” nor any other vague adjective) was published by Baran lab.
The step that impressed me the most was oxidation of compound 7. Chemo-, regio-, and stereoselectivity of this reaction was “easily predictable based on 100 years of C–H oxidation literature”, according to follow-up blog post, but I wonder how many chemists in the world would bet for this reaction to work so cleanly. Before reading the publication, of course.
Koh et al. (Hoveyda lab, Nature)
Expanding horizons of the metathesis reaction, Hoveyda lab teamed up with Schrock and developed a new catalyst and synthetic methodology for terminal Z-haloalkenes.
Battilocchio, Feist et al (Nat Chem)
Remember Morken reaction? I was daydreaming about streamlining it into bond-by-bond stitching of complex compounds. Turns out that Steven Ley was looking in the same direction, although through slightly different chemistry.
A nice example of ‘molecular gymnastics’ (proposed mechanism is quite a funny thing). Heads up from amphoteros blog.
Potter et al (JOC)
Safety first! Opt for hydrosulfate salt next time you prepare a diazotransfer reagent. I didn’t have problems with hydrochloride before, but will better give a try to hydrosulfate.
…but hurry up with your diazotransfer, otherwise machines will soon do it for you! A fridge-sized synthesizer of known pharmaceuticals was constructed by chemists and engineers in MIT. Check out more detailed (and realistic) coverage by Derek Lowe.