OC tidbits #4

BΓΌschleb et al. (ACIE)

A collection of OC tidbits selected by Hanessian and Overman groups. Featuring a dozen of natural products, each full of densely-packed stereocenters; 29 oldschoolishly lengthy synthetic schemes including three hundred intermediates that undergo all sorts of electrocyclic reactions and crazy cascades. Read in limited quantities to prevent overexcitement.

And, of course, I liked this guy (or girl?) at the frontispiece (the only thing one can get for free from Angewandte preview without subscription) in high-energy conformation overcoming some activation barrier.

completedSyn

Nicolaou et al (JACS)

KCN loves gold.

nicolaou-2

Picado et al. (JOC)

Turning failures into victories: if the reaction works, it’s just another row in a table. If it doesn’t, it can be a whole new paper!

joc-fail

Pan, Qin et al. (Org Lett)

A question without answer: how come this stereochemistry

panqin.png

… given this:

panqin2.png

 

Patil et al. (JOC)

Simplicity is the new beauty (via orgchem.by).

oximes

Mishra and Biswas (JOC)

Another example of beautiful simplicity.

mishra.png

Babij, McCuscer et al. (OPR&D)

Expanded list of chemical shifts for commond (and not so common but green) solvents [open access!]

op-2015-00417r_0006

 

 

True power of 1D NMR

An interesting case study of a correct structure assignment for aquatolide appeared in JOC. It’s interesting from several points of view. First, it nicely shows how one can effectively use reach information from free induction decay (FID), which is lost (or masked) in Fourier-transformed spectra. Second, it emphasizes importance of data sharing and demonstrates crucial role of ‘research parasites‘ in scientific ecosystem. Third, the paper has seven-point manifest in the conclusions section. Continue reading “True power of 1D NMR”

PSYCHEDELIC 2DJ NMR

Although originally developed by physicists, NMR is one of those technologies that revolutionized chemistry. With enormous recent advances, it became a great tool for interrogating complex structures of peptides and nucleic acids. But there’s still plenty of room for improvement in the most basic its application, proton (1H) NMR. Continue reading “PSYCHEDELIC 2DJ NMR”